Principal Scientist – Computational Protein Design & Engineering
PharmaEssentia U.S.A.Massachusetts, United States
Posted October 3, 2025
Full Time
About the Company
PharmaEssentia USA Corporation, a subsidiary of PharmaEssentia Corporation, is a global biopharmaceutical innovator specializing in the development and delivery of new biologics for hematology, oncology, and immunology. With a focus on rare diseases and orphan drugs, the company leverages deep expertise and proven scientific principles to advance drug development. Founded in 2003, PharmaEssentia has expanded its global presence across the U.S., Japan, China, and Korea.
Job Description
PharmaEssentia is a global biopharmaceutical company focused on developing innovative therapies. They are seeking a highly motivated Principal Scientist – Computational Protein Design & Engineering to join their Biologics Platform team. The role involves utilizing computational methods to design, engineer, and optimize biologics, working closely with Biologics Platform team members to deliver transformative therapies.
Requirements
- Ph.D. in Computational Protein Design, Structural Biology, Protein Engineering, or a related field
- 6+ years of industry experience applying computational modeling to protein design and antibody engineering
- Proficiency with leading modeling tools such as AlphaFold, RoseTTAFold, ProteinMPNN, MOE, or Schrödinger
- Expertise in leveraging structural modeling, epitope prediction, repertoire mining, protein language models, and AI/ML techniques
- Demonstrated leadership in advancing discovery programs
