Director, Medicinal Chemistry

Join Flagship Labs 107 (FL107) as Director of Medicinal Chemistry to lead small molecule discovery efforts across multiple programs, leveraging DNA-encoded library and covalent fragment screening, AI/ML-driven generative chemistry, and structure-based design. Build the execution engine and help shape the platform and portfolio of a high-growth company from the ground up.

Requirements

• PhD in Organic or Medicinal Chemistry experience in small molecule drug discovery
• Proven track record advancing multiple programs through hit-to-lead and lead optimization
• Demonstrated success working with emerging modalities (e.g., molecular glues, bifunctional molecules, induced proximity)
• Deep understanding of structure-based drug design, SAR optimization, and balancing key parameters (potency, ADME/PK, physicochemical properties)
• Experience managing distributed CRO teams, external synthesis workflows, and global chemistry partnerships
• Strong cross-functional collaboration skills; fluent in communicating with biology, DMPK, IP, and data science stakeholders
• Strategic mindset with strong scientific judgment, organizational leadership, and a drive to move with urgency
• Excellent communication and synthesis skills, with the ability to present structured updates on complex scientific concepts to technical, non-technical, and executive audiences
• Strong analytical skills with the ability to interpret complex datasets and derive meaningful insights
• Proven ability to work effectively in a collaborative team environment and manage multiple projects simultaneously
• Resourceful problem solver and self-starter

Benefits

• Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests
• Weekly lunches, monthly social events, and community lunchroom with free snacks, cold brew coffee tap, and a vibrant community with scientists and entrepreneurs
• A collaborative and inclusive work environment that values diversity and innovation
• Access to state-of-the-art facilities and cutting-edge technologies
• Annual incentive program, retirement benefits, and a broad range of other benefits