Sr Scientist I (Process Chemistry)

The Senior Scientist I, Process Chemistry, will focus mainly on executing in-house process chemistry efforts at Exelixis process research and development lab. This individual will work with medicinal discovery chemist to evaluate synthetic routes for early-stage discovery projects to facilitate smooth scale up for supply of compounds for pre-clinical studies, understand the physical and chemical properties of compounds of interest and perform solid state polymorph screening to define the stable polymorph for DS manufacturing, tech transfer the processes developed in lab to CMO for clinical manufacturing and work with project teams for troubleshooting and problem solving for ongoing manufacturing projects.

Requirements

• Work with discovery teams to evaluate synthetic routes and test alternatives that facilitate scale up of both target compounds and building blocks while providing insights for selection of development candidates.
• Execute in-house process development and optimization studies to facilitate scale up and transfer to CMOs.
• Collaborate with project team to source appropriate starting materials.
• Prepare technical packages for transfer of processes to CMO/CRO partner facilities.
• Knowledge of characterization of the physical and chemical properties of compounds of interest and perform solid state characterization and polymorph screening.
• Partner with Manufacturing, Formulation Development, Analytical Chemistry, Quality Control and Quality Assurance to ensure drug substances are delivered on time and within specification.
• Write and review CMC sections of regulatory filings when needed.
• Keep abreast of all relevant publications and guidance documents.

Benefits

• 401k plan with generous company contributions
• group medical, dental and vision coverage
• life and disability insurance
• flexible spending accounts
• discretionary annual bonus program
• sales-based incentive plan
• opportunity to purchase company stock
• long-term incentives
• 15 accrued vacation days in their first year
• 17 paid holidays including a company-wide winter shutdown in December
• up to 10 sick days throughout the calendar year