Director, Chemical Development (Process Chemist)

Calico is seeking an experienced Director of Chemical Development to lead process chemistry and manufacturing for small molecule programs. The role requires deep technical expertise, leadership, and cross-functional collaboration.

Requirements

• Ph.D. in Organic Chemistry
• Minimum 15 years of experience in process chemistry
• Demonstrated experience in route design, process scale-up, and cGMP manufacturing
• Proven track record in supporting regulatory submissions and health authority interactions
• Solid background in Quality by Design, modern process analytical technology, risk management, and process validation
• Understanding of current regulatory guidances
• Expertise with solid-state chemistry, crystallization, and particle engineering
• Experience managing CDMOs and CROs with a focus on quality, cost, and delivery
• Strong problem-solving, project management, and communication skills
• Ability to lead cross-functional teams and mentor junior staff

Benefits

• Estimated base salary range: $238,000 - $250,000
• Eligible for two annual cash bonuses